Current Issue : January - March Volume : 2021 Issue Number : 1 Articles : 5 Articles
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Biodegradable and biocompatible copolymers have been often studied for the development\nof biomaterials for drug delivery systems. In this context, this work reports the synthesis and\ncharacterization of a novel pullulan-g-poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (Pull-g-PHBHV)\ngraft copolymer using click chemistry. Well-defined and functional pullulan backbones containing\nazide groups,....................................
A novel family of water-soluble pi-conjugated hexaazatrinaphthylenes-based dendritic\narchitectures constructed by hexaketocyclohexane and 1,2,4,5-benzenetetramine units is developed\nin a microwave-assisted organic synthesis (MAOS) approach. The structures and purity of these\ncompounds are verified by 1H and 13C-NMR, MALDI-TOF MS, UV-vis, elemental analysis, DSC,\nAFM, STM and cyclic voltammetry....
A series of benzylidene-3-pyrrolines were prepared from chalcone derivatives,\narylacetylene and sulfonamide via a three-step sequence without the isolation of intermediates.\nTypically, the reaction of 1,3-di-p-tolylprop-2-en-1-one with lithium phenylacetylide was\nfollowed by substitution with tosylamide and then silver-catalyzed 5-exo-dig cyclization to\ngive N-tosyl-2-benzylidene-3,5-di-p-tolyl-2,5-dihydro-1H-pyrrole with a 86% yield. Furthermore,\ntransformation to the corresponding substituted 3-pyrrolin-2-one and pyrrole by m-chloroperbenzoic\nacid (mcpba)-oxidation and acid-catalyzed aromatization, respectively, was investigated....
Background: Imidazo[2,1-b]thiazole scaffolds were reported to possess various\npharmaceutical activities. Results: The novel compound named methyl-2-(1-(3-methyl-6-(ptolyl)\nimidazo[2,1-b]thiazol-2-yl)ethylidene)hydrazine-1-carbodithioate 3 acted as a predecessor\nmolecule for the synthesis of new thiadiazole derivatives incorporating imidazo[2,1-b]thiazole\nmoiety. The reaction of 3 with the appropriate hydrazonoyl halide derivatives 4aâ??j and 7â??9 had\nproduced the respective 1,3,4-thiadiazole derivatives 6aâ??j and 10â??12. The chemical composition of\nall the newly synthesized derivatives were confirmed by their microanalytical and spectral data\n(FT-IR, mass spectrometry,.....................................
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